1. Objective: To investigate the anti-tumor mechanism of hirudin.
目的：探讨复方水蛭素抗肿瘤的作用机理。
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2. PurposeThe aim is to obtain recombinant hirudin gene using PCR method.
目的应用PCR方法获得水蛭素基因。
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3. The anticoagulation effect of hirudin was better than dipyridamole (P
水蛭素抗凝作用明显强于潘生丁（P
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4. Hirudin has good pharmacological action, which is widely used in clinical practice.
水蛭素具有较好的药理作用，其药源丰富，在临床上应用广泛。
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5. Results The drug content of prepared recombinant hirudin coated-pellets was 3.513% (w).
结果所制备的重组水蛭素肠溶包衣微丸药物含量质量分数为3.513%。
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6. OBJECTIVE: To investigate the protective effect of hirudin on random skin flap congestion.
目的：观察水蛭素对大鼠随意皮瓣淤血模型成活保护作用。
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7. Conclusion Damage to the thalamic tissue might be caused by thrombin and reversed by hirudin.
结论凝血酶对丘脑组织具有毒性损伤作用，但这一损伤可被水蛭素逆转。
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8. OBJECTIVE Progress in different routes of administration and formulations for Hirudin are reviewed.
目的阐述水蛭素不同给药途径及相关剂型的研究进展。
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9. AIM: To directed promote the antithrombotic activity of hirudin in vitro with DNA family shuffling method.
目的：运用DNA家族改组方法提高水蛭素的抗凝血酶活性。
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10. As a direct thrombin inhibitor, recombinant hirudin (r-hirudin) has played an important role in clinical use.
作为直接凝血酶抑制剂，重组水蛭素在临床上的应用已越来越重要。
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11. However, low production of natural hirudin, which was very expensive, limiting its use of in clinical practice.
但是天然水蛭素产量低，价格昂贵，限制了它在临床上的运用。
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12. ConclusionThe experiments show that hirudin active factors have strong inhibition effect on S180 Tumor and CAM angiogenesis.
结论实验表明，水蛭素活性因子对S180肿瘤和CAM新生血管具有较强的抑制作用。
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13. Objective To investigate the mechanism of brain injury caused by thrombin and the intervention effect of hirudin and nimodipine.
目的探讨凝血酶对脑组织损害的机制，及凝血酶抑制剂水蛭素和尼莫地平对其的影响。
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14. ObjectiveTo explore the effect of hirudin active factor on S180 tumor and angiogenesis so as to provide the theoretical basis for clinical medication.
目的探讨水蛭素活性因子对S180肿瘤及血管新生的影响，为临床用药提供理论依据。
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15. Conclusion Thrombin lead to brain edema after cerebral hemorrhage that could be restrained by hirudin, and hirudin didn't produce any negative effect on brain tissue.
16. CONCLUSION The transport of recombinant hirudin across xenopus pulmonary membrane was a passive diffusion process which was energy-independent and carrier-independent.
结论重组水蛭素经蟾蜍肺泡膜的转运是一个非能量依赖、非载体依赖的被动扩散过程。
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17. The pharmacological action, dose, security and stability of hirudin are summarized, and its availability is analyzed to provide some references for the relevant research.
从水蛭素药理作用、剂量及安全性、稳定性方面，对水蛭素的可利用性进行了分析，旨在为相关研究奠定基础。
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18. Conclusion Thrombin can lead to brain edema after cerebral hemorrhage which can be restrained by hirudin. And then, hirudin doesn't produce any negative effect on brain tissue.
19. AIM to investigate the apoptotic effect of thrombin on brain microvascular endothelial cell (BMVEC) of cultured rat, and the protective effect of hirudin, an inhibitor of thrombin.
20. The successful display of hirudin on the surface of M13 phage laid a sound foundation for the further study on directed evolution of antithrombotic proteins with altered properties.
水蛭素在噬菌体表面的功成展示为进一步开展其实验定向进化以及结构与功能关系的研究打下基础。
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21. Hirudin is an anticoagulant directly acting on thrombin. Its molecular biological and pharmacological properties, mechanism of action, current clinical researches and USES were reviewed.
22. Results:Thrombin soaked gelatin sponges caused significant brain edema in the right basal ganglia. Hirudin prevented thrombin induced edema. Conclusion:Thrombin soaked gelation sponges can cause o…
结果：在同侧基底节，明胶海绵吸附上凝血酶引起明显脑水肿，水蛭素能减轻脑水肿。
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23. This paper introduces their mechanism function and clinical research illustrates their advantages compated with heparin believing that both hirudin and hirulog are new promising antithrombotic agents.
24. This paper introduces their mechanism function and clinical research illustrates their advantages compated with heparin believing that both hirudin and hirulog are new promising antithrombotic agents.
