"to poison," mid-15c., from Medieval Latin intoxicatus, past participle of intoxicare "to poison," from Latin in- "in" (see in- (2)) + toxicare "to poison," from toxicum "poison" (see toxic). Meaning "make drunk" first recorded 1570s. Related: Intoxicated; intoxicating.[intoxicate etymology, intoxicate origin, 英语词源]